Adaptive Mutation Requires No Mutagenesis—Only Growth Under Selection: A Response
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Adaptive Mutation Requires No Mutagenesis— Only Growth Under Selection: A Response
IN a bacterial system devised by Cairns and Foster The letter from Cairns and Foster (2003, this issue) (1991), a lac mutant population, starved in the pressuggests that our calculations are in error because we ence of lactose, gives rise to 100 revertant colonies extrapolated from rates observed or inferred for genes over 6 days. In this time, the plated population is not on an F plasmid to pr...
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Growth under selection causes new genotypes to predominate in a population. It is difficult to determine whether selection stimulates formation of new mutations or merely allows faster growth of mutants that arise independent of selection. In the practice of microbial genetics, selection is used to detect and enumerate pre-existing mutants; stringent conditions prevent growth of the parent and ...
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The classical experiments of Luria and Delbrück showed convincingly that mutations exist before selection and do not contribute to the creation of mutations when selection is lethal. In contrast, when nonlethal selections are used,measuring mutation rates and separating the effects of mutation and selection are difficult and require methods to fully exclude growth after selection has been appli...
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The behavior of a particular bacterial genetic system has been interpreted as evidence that selective stress induces general mutagenesis or even preferentially directs mutations to sites that improve growth (adaptive mutation). It has been proposed that changes in mutability are a programmed response to stress in non-growing cells. In contrast, the amplification-mutagenesis model suggests that ...
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ژورنال
عنوان ژورنال: Genetics
سال: 2003
ISSN: 1943-2631
DOI: 10.1093/genetics/165.4.2319